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You should not use ticagrelor if you have severe liver disease, any active bleeding (including a bleeding stomach ulcer), or a history of bleeding in the brain. Do not use Brilinta just before heart bypass surgery (coronary artery bypass graft, or CABG).

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Many drugs (including some over-the-counter medicines and herbal products) can cause serious medical problems if you take them with ticagrelor. It is very important to tell your doctor about all medicines you have recently used.

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